HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → (RS)-2-[4-(3-chloro-benzyloxy)-phenoxy]-N-methyl-propionamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-(Bromomethyl)-3-chlorobenzene | HCID 69838 | — |
| Reactant | HCID 18539804 | HCID 18539804 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | (RS)-2-[4-(3-chloro-benzyloxy)-phenoxy]-N-methyl-propionamide | HCID 69040582 | — |
Reaction Steps
In analogy to the procedure described in Example 3b), the alkylation of (RS)-2-(4-hydroxy-phenoxy)-N-methyl-propionamide with 3-chloro-benzylbromide in 2-butanone using potassium carbonate as the base yielded the (RS)-2-[4-(3-chloro-benzyloxy)-phenoxy]-N-methyl-propionamide as a white solid; MS: m/e=320 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07253318B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-1a2403e1c66e4f9b8394b34048b0a3a2 |
| Source note | uspto-grants-2007_08 |