HCID 69037597, compound → HCID 69039171, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 500 mg of 3-[4-(3-fluoro-benzyloxy)-phenoxy]-propionic acid methyl ester in a mixture of 5 ml of tetrahydrofurane and 25 ml of hydrochloric acid (19%) was heated at 70° C. for 7 h. For the working-up, the tetrahydrofurane was evaporated under reduced pressure and the aqueous was extracted three times with 40 ml of ethyl acetate. The combined organic layers were dried over magnesium sulphate and evaporated under reduced pressure. The crude product was triturated in ether and the solid material collected on a filter funnel. After drying there were obtained 114 mg (30% of theory) of 3-[4-(3-fluoro-benzyloxy)-phenoxy]-propionic acid as white crystals.

Provenance & Evidence