Trifluoroacetic acid → HCID 11687874, compound

Participants

Reaction Steps

Under an argon atmosphere and at room temperature, a suspension of 1.0 g of 2-[4-(3-fluoro-benzyloxy)-phenyl]-ethanol and 0.66 g of potassium isocyanate in 2 ml of benzene was treated dropwise under stirring with 0.62 ml of trifluoroacetic acid. After stirring for 18 h at room temperature, the reaction mixture was diluted with water, then extracted three times with dichloromethane. The combined organic layers were dried over potassium carbonate and evaporated. There were obtained 0.52 g (44% of theory) of carbamic acid 2-[4-(3-fluoro-benzyloxy)-phenyl]-ethyl ester as a white solid; MS: m/e=290 (M+H)+.

Provenance & Evidence