Sertraline → Sertraline Hydrochloride

Participants

Reaction Steps

30 g sertraline base is dissolved in 450 ml acetonitrile at room temperature. To this solution a solution of 13.3 g dimethylacetamide hydrochloride in 150 ml acetonitrile is added under stirring within 15 minutes. While adding solution of dimethylacetamide hydrochloride sertraline hydrochloride precipitates nicely in the crystalline Form II. After stirring the suspension for another hour, the product is filtered off, washed twice with 50 ml acetone and dried at 50° C. under vacuum for three hours to yield 31.3 g (94%) of sertraline hydrochloride form II.

Provenance & Evidence