HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sertraline → Sertraline Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sertraline | HCID 68617 | — |
| Reactant | 1-Methylpyrrolidin-2-one--hydrogen chloride (1/1) | HCID 18629821 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Sertraline Hydrochloride | HCID 63009 | 95.1% |
Reaction Steps
20 g sertraline base is dissolved in 300 ml acetonitrile at room temperature. To this solution a solution of 9.75 g N-methylpyrrolidin-2-on hydrochloride in 100 ml acetonitrile is added under stirring within 15 minutes. After stirring for 45 minutes, the crystals are filtered off, washed twice with 40 ml acetone and dried at 50° C. under vacuum for three hours to yield 21.28 g (95%) of sertraline hydrochloride form II.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07253320B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-38be23fb2c9848b7b4ee47d461d932f6 |
| Source note | uspto-grants-2007_08 |