Sertraline → Sertraline Hydrochloride

Participants

Reaction Conditions

Reaction Steps

3 g sertraline base is dissolved in 45 ml acetonitrile at room temperature. The solution is cooled to 0° C. whereby a suspension is formed. A solution of 1.33 g dimethylacetamide hydrochloride in 15 ml acetonitrile is added under stirring within one minute. During the addition of the solution the temperature increases to about 8° C. and sertraline hydrochloride precipitates. After stirring for one hour at 0° C. the crystalline product is filtered off and dried at 50° C. under vacuum to yield 3.28 g (98%) of sertraline hydrochloride form II.

Provenance & Evidence