HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 853176Generated: October 30, 2026
HCID 523006, compound → Sertraline Hydrochloride
https://huagongshe.com/reaction/853176
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | HCID 523006 | HCID 523006 | — |
| Reactant | (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine;2-hydroxy-2-phenylacetate | HCID 131718189 | — |
| Solvent | Methyl Isobutyl Ketone | HCID 7909 | — |
| Product | Sertraline Hydrochloride | HCID 63009 | 94.1% |
Reaction Steps
A suspension of 2 g sertraline mandelate in 40 ml methyl isobutyl ketone is heated at 80° C. and 0.6 g dimethylacetamide hydrochloride in solid form is added. The suspension is stirred at 80° C. for 30 minutes and then cooled down to room temperature. After stirring for about one hour, the product is filtered off and dried at 50° C. under vacuum to yield 1.41 g (94%) of sertraline hydrochloride Form II.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07253320B2 |
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| Source dataset | uspto-grants-2007_08 |
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| ORD ID | ord-358e9b22b6b34ebca7b85e99b7c23c54 |
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| Source note | uspto-grants-2007_08 |
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