Sertraline → Sertraline Hydrochloride

Participants

Reaction Steps

3 g of sertraline base in 60 ml n-butanol are heated to 50° C. 1.21 g N,N-dimethylacetamide hydrochloride are added. The suspension is kept for approximately 10 min at 50° C. and is then allowed to cool to ambient temperature within 1 hour. The product is then isolated by filtration and dried at 50° C. under vacuum to yield 2.16 g (65%) of Sertraline hydrochloride form II.

Provenance & Evidence