6-Bromo-4,4-dimethyl-3,4-dihydronaphthalen-1(2H)-one → 5-bromo-3,3-dimethyl-2,3-dihydro-1H-inden-1-one

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Reaction Steps

Following a procedure similar to that for the preparation of 6-bromo-4,4-dimethyl-3,4-dihydro-2H-naphthalen-1-one (Compound 3) while using 6-bromo-1,1-dimethyl-indan (Compound 11, 2.45 g, 10.9 mmol) as the starting material afforded the title compound (1.95 g, 75% yield) as a white solid:

Provenance & Evidence