Potassium ethanethioate → HCID 86603215, compound

Participants

Reaction Steps

1-(tert-butyloxycarbonylamino)-3-iodopropan-2-ol (example 22a) (2 g, 6.64 mmol) and potassium thioacetate (0.948 g, 8.30 mmol) were dissolved in acetone (30 ml) and the medium was refluxed for 16 hours. The solvent was vacuum evaporated and the residue was taken up in diethyl ether, then filtered on Celite®. The filtrate was evaporated. The residue obtained (1.69 g) was purified by chromatography on silica gel (eluent: dichloromethane/ethyl acetate 98:2) then repurified by flash chromatography (eluent: dichloromethane) to give the desired compound in the form of a yellow oil.

Provenance & Evidence