反应详情

4-(4-Amino-3-fluorophenoxy)-6-cyano-7-(2-methoxyethoxy)quinoline (100 mg) was added to 4.5 ml of toluene, and the mixture was heated to reflux. After then adding 2-fluorophenyl isocyanate (0.05 ml), the mixture was further heated to reflux for 1 hour. After cooling, the precipitated solid was filtered out and washed with ethyl acetate/toluene==1/1 to obtain 100 mg of the title compound as light brown crystals (72% yield).

1. temperaturethe mixture was heated to reflux
2. temperatureto reflux for 1 hour
3. temperatureAfter cooling
4. filtrationthe precipitated solid was filtered out
5. washwashed with ethyl acetate/toluene==1/1