Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 2-Aminopyridine | HCID 10439 | — |
| Reactant | HCID 22936720 | HCID 22936720 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 22936538 | HCID 22936538 | 54.7% |
Reaction Steps
Phenyl N-(4-(6-cyano-7-methoxy-4-quinolyl)oxyphenyl)carbamate (150 mg) and 2-aminopyridine (69 mg) were dissolved in 1 ml of dimethylsulfoxide, and the solution was heated and stirred at 80° C. for 1.5 hours. After cooling, water was added, and the precipitated solid was filtered out and washed with ethyl acetate to obtain 82 mg of the title compound as light brown crystals (54% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07253286B2 |
|---|
| Source dataset | uspto-grants-2007_08 |
|---|
| ORD ID | ord-f3f969363c134024b5a28d694bbf221b |
|---|
| Source note | uspto-grants-2007_08 |
|---|
