反应详情

温度

80 °C

To 10 ml of anhydrous acetic acid was added 2.7 g (8.2 mmol) of 4-[(3-benzyloxyphenyl)butylamino]-1-butanol and the mixture was stirred with heating at 80° C. for 1 hour. The reaction mixture was poured into 150 ml of water and subjected to extraction with ethyl acetate. Washing was performed with a saturated sodium bicarbonate solution and then with a saturated saline solution. Drying over anhydrous sodium sulfate and concentration were performed. The residue was purified by silica gel column chromatography to give 2.68 g of a colorless oily matter (yield: 88.0%).

1. extractionsubjected to extraction with ethyl acetate
2. washWashing
3. dry with materialDrying over anhydrous sodium sulfate and concentration
4. customThe residue was purified by silica gel column chromatography
5. customto give 2.68 g of a colorless oily matter (yield: 88.0%)