4-Fluorophenyl isocyanate → HCID 58930909, compound

HRID 853295Notes

Reaction equation

HRID 853295 reaction equation
[NH2:1][C:2]1[CH:22]=[CH:21][C:5]([O:6][C:7]2[C:8]3[CH:15]=[C:14]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[NH:13][C:9]=3[N:10]=[CH:11][N:12]=2)=[CH:4][CH:3]=1.[F:23][C:24]1[CH:29]=[CH:28][C:27]([N:30]=[C:31]=[O:32])=[CH:26][CH:25]=1>C1(C)C=CC=CC=1.C(#N)C>[CH2:19]([O:18][C:16]([C:14]1[NH:13][C:9]2[N:10]=[CH:11][N:12]=[C:7]([O:6][C:5]3[CH:21]=[CH:22][C:2]([NH:1][C:31]([NH:30][C:27]4[CH:28]=[CH:29][C:24]([F:23])=[CH:25][CH:26]=4)=[O:32])=[CH:3][CH:4]=3)[C:8]=2[CH:15]=1)=[O:17])[CH3:20]

Participants

5

Reactant 2

HCID 709554-Fluorophenyl isocyanateHCID 58931023HCID 58931023, compound

Product 1

HCID 58930909HCID 58930909, compound

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 6342AcetonitrileSolvent

Procedure

After dissolving 90 mg of ethyl 4-(4-aminophenoxy)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate in 3 ml of toluene and 1 ml of acetonitrile at 110° C., 16.6 μl of 4-fluorophenyl isocyanate was added and the mixture was stirred for 1 hour under reflux. After standing at room temperature, the precipitated crystals were filtered out and dried to obtain 110 mg of the title compound.

Workup

  1. temperatureunder reflux
  2. customAfter standing at room temperature
  3. filtrationthe precipitated crystals were filtered out
  4. customdried

Sources & evidence

ORD record
ord-b6e21c4749db49b3907a6852607fc0af
Source dataset
uspto-grants-2007_08
Patent number
US07253286B2

Reaction notes

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