4-Fluorophenyl isocyanate → HCID 58931453, compound

HRID 853301Notes

Reaction equation

HRID 853301 reaction equation
[C:1]1([C:7]2[NH:23][C:10]3[N:11]=[CH:12][N:13]=[C:14]([O:15][C:16]4[CH:21]=[CH:20][C:19]([NH2:22])=[CH:18][CH:17]=4)[C:9]=3[CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[F:24][C:25]1[CH:30]=[CH:29][C:28]([N:31]=[C:32]=[O:33])=[CH:27][CH:26]=1>C1(C)C=CC=CC=1.C(#N)C>[F:24][C:25]1[CH:30]=[CH:29][C:28]([NH:31][C:32]([NH:22][C:19]2[CH:20]=[CH:21][C:16]([O:15][C:14]3[C:9]4[CH:8]=[C:7]([C:1]5[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=5)[NH:23][C:10]=4[N:11]=[CH:12][N:13]=3)=[CH:17][CH:18]=2)=[O:33])=[CH:27][CH:26]=1

Participants

5

Reactant 2

HCID 709554-Fluorophenyl isocyanateHCID 589311894-(6-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenylamine

Product 1

HCID 58931453HCID 58931453, compound

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 6342AcetonitrileSolvent

Procedure

After dissolving 40 mg of 4-(6-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenylamine in 4.5 ml of toluene and 4.5 ml of acetonitrile at 110° C., 4-fluorophenyl isocyanate (16.6 μl) was added and the mixture was stirred for 1 hour. After returning the mixture to room temperature, the precipitated crystals were filtered out and dried to obtain 37 mg of the title compound.

Workup

  1. customto room temperature
  2. filtrationthe precipitated crystals were filtered out
  3. customdried

Sources & evidence

ORD record
ord-6930f81808d5445d97b504c38add1fe7
Source dataset
uspto-grants-2007_08
Patent number
US07253286B2

Reaction notes

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