Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → 2-{[7-(Benzyloxy)-6-methoxy-4-quinolyl]sulfanyl}-5-nitrothiophene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-Bromo-5-nitrothiophene | HCID 83222 | — |
| 반응물 | 7-(Benzyloxy)-6-methoxy-1,4-dihydro-4-quinolinethione | HCID 22936980 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2-{[7-(Benzyloxy)-6-methoxy-4-quinolyl]sulfanyl}-5-nitrothiophene | HCID 58931211 | 76.9% |
반응 단계
7-(Benzyloxy)-6-methoxy-1,4-dihydro-4-quinolinethione (14.3 g), 2-bromo-5-nitrothiophene (10 g), potassium carbonate (9.9 g) and dimethylformamide (150 ml) were stirred together at room temperature for 6 hours. Water was added, and the precipitated solid was filtered out and washed with water and then ethyl acetate to obtain 15.7 g of a yellow powder.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07253286B2 |
| 출처 데이터셋 | uspto-grants-2007_08 |
| ORD ID | ord-491a19dcf87a45adac6c3f97a86295bf |
| 출처 메모 | uspto-grants-2007_08 |