1-Propanamine, 3-chloro-, hydrochloride → HCID 22936526, compound

HRID 853405Notes

Reaction equation

HRID 853405 reaction equation
Cl.[Cl:2][CH2:3][CH2:4][CH2:5][NH2:6].[CH3:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].[C:13]([O:16]CC)(=[O:15])C>C(OCC)C.CCCCCC>[Cl:2][CH2:3][CH2:4][CH2:5][NH:6][C:13](=[O:15])[O:16][C:9]1[CH:8]=[CH:7][CH:12]=[CH:11][CH:10]=1

Participants

5

Reactant 2

HCID 114690951-Propanamine, 3-chloro-, hydrochlorideHCID 21226206Ethyl acetate hexane

Product 1

HCID 22936526HCID 22936526, compoundYield 40.4%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 8058HexaneSolvent

Procedure

3-Chloropropylaminehydrochloride (6.5 g, 50 mmol) was used for reaction in the same manner as Production Example 310-1, purification was performed by silica gel column chromatography (hexane/ethyl acetate system), the obtained crystals were suspended in diethyl ether and diluted with hexane, and the crystals were filtered out, washed with hexane and dried by aspiration to obtain the title compound (4.316 g, 20.20 mmol, 40.40%) as colorless crystals.

Workup

  1. filtrationthe crystals were filtered out
  2. washwashed with hexane
  3. customdried by aspiration

Sources & evidence

ORD record
ord-9336b661b4ac4da99296dd19e2ddb603
Source dataset
uspto-grants-2007_08
Patent number
US07253286B2

Reaction notes

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