HCID 67202400, compound → Methyl 4-hydroxyfuro[2,3-B]pyridine-2-carboxylate

HRID 853494Notes

Reaction equation

HRID 853494 reaction equation
[CH3:1][O:2][C:3]([C:5]1[O:6][C:7]([NH:10][CH:11]=[C:12]2[C:17](=[O:18])OC(C)(C)OC2=O)=[CH:8][CH:9]=1)=[O:4]>C1C=CC(C2C=CC=CC=2)=CC=1.C1C=CC(OC2C=CC=CC=2)=CC=1>[CH3:1][O:2][C:3]([C:5]1[O:6][C:7]2[NH:10][CH:11]=[CH:12][C:17](=[O:18])[C:8]=2[CH:9]=1)=[O:4]

Participants

3

Reactant 1

HCID 67202400HCID 67202400, compound

Product 1

HCID 58931135Methyl 4-hydroxyfuro[2,3-B]pyridine-2-carboxylateYield 76.4%

Reagents, catalysts & solvents 1

HCID 246701,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene)Solvent

Conditions

Temperature
200 °C

Procedure

After adding 5-[(2,2-dimethyl-4,6-dioxo-[1.3]dioxan-5-ylidenemethyl) amino]furan-2-carboxylic acid methyl ester (4.0 g) to Dowtherm A (30 ml), the mixture was heated and stirred at 200° C. for 1 hour. After cooling, the precipitated crystals were filtered out and washed with diethyl ether to obtain the title compound (2.0 g).

Workup

  1. temperaturethe mixture was heated
  2. temperatureAfter cooling
  3. filtrationthe precipitated crystals were filtered out
  4. washwashed with diethyl ether

Sources & evidence

ORD record
ord-0ea451057552421a9549ea6719142115
Source dataset
uspto-grants-2007_08
Patent number
US07253286B2

Reaction notes

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