HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 4-(4-(4-Aminophenoxy)-6-cyanoquinolin-7-yloxymethyl)-piperidine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | tert-Butyl 4-(2-bromoethyl)piperidine-1-carboxylate | HCID 10541625 | — |
| Reactant | 4-(4-Aminophenoxy)-6-cyano-7-hydroxyquinoline | HCID 135829390 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-(4-(4-Aminophenoxy)-6-cyanoquinolin-7-yloxymethyl)-piperidine-1-carboxylic acid tert-butyl ester | HCID 67202924 | — |
Reaction Steps
After treating 4-(4-aminophenoxy)-7-hydroxyquinoline-6-carbonitrile (0.32 g) with sodium hydride in dimethylformamide in the same manner as Production Example 713-2, it was reacted with 4-bromoethylpiperidine-1-carboxylic acid tert-butyl ester to obtain the title compound (225 mg) as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07253286B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-5d9da565e242425bbba4355833b223d7 |
| Source note | uspto-grants-2007_08 |