反应详情

From 9 (610 mg, 2.5 mmol) and 2-methoxybenzylzinc chloride (0.5 M in THF, 10 mL, 5 mmol) by the same method as 10a; white powder (364 mg, 61%): mp 77.5-78.5° C.; 1H NMR (CDCl3) δ 3.81 (s, 3H, OMe), 3.82 (s, 2H, CH2), 4.25 (br s, 2H, NH2), 6.64 (d, J=8.0 Hz, 1H, H-3), 6.85-6.88 (m, 2H, H-3′ and H-5′), 7.06 (d, J=7.2 Hz, 1H, H-6′), 7.18-7.23 (m, 3H, H-4′, H-4, and H-6).