Zinc → HCID 178491864, compound

Participants

Reaction Steps

3,4,5-Trimethoxybenzylzinc chloride was prepared from 3,4,5-trimethoxybenzyl chloride (867 mg, 4 mmol) and reactive metallic zinc suspension (0.76 M in THF, 6.3 mL, 4.8 mmol). The supernatant was transferred via a cannula into a solution of 9 (244 g, 1 mmol) in THF, followed by the usual workup; pale-yellow oil (127 mg, 43%): 1H NMR (CDCl3) δ 3.78 (s, 2H, CH2), 3.81 (s, 6H, 3′- and 5′-OMe), 3.82 (s, 3H, 4′-OMe), 4.28 (br s, NH2), 6.30 (s, 2H, H-2′ and H-6′), 6.69 (d, J=8.4 Hz, 1H, H-3), 7.16 (d, J=8.4 Hz, 1H, H-4), 7.19 (s, 1H, H-6).

Provenance & Evidence