HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 2-(2-hydroxybenzamido)propylcarbamate → N-(1-aminopropan-2-yl)-2-hydroxybenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 2-(2-hydroxybenzamido)propylcarbamate | HCID 67493246 | — |
| Solvent | Hydrochloride methanol | HCID 21893726 | — |
| Product | N-(1-aminopropan-2-yl)-2-hydroxybenzamide | HCID 63732371 | 113.6% |
Reaction Steps
A mixture of tert-butyl 2-(2-hydroxybenzamido)propylcarbamate (2.4 g, 8.16 mmol) in saturated HCl-MeOH (50 mL) was stirred (RT, 2 h) and concentrated under reduced pressure to afford N-(1-aminopropan-2-yl)-2-hydroxybenzamide (1.8 g, 96%) as a white solid. Mass calculated for C10H14N2O2=194.23; found: [M+H]+=195.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08846972B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-477daf68843c43a68983f42d8b5513d0 |
| Source note | uspto-grants-2014_09 |