Water → HCID 135753977, compound

HRID 853787Notes

Reaction equation

HRID 853787 reaction equation
[C:1]1([C:7]2[NH:12][C:11](=[O:13])[CH:10]=[C:9]([C:14]3[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=3)[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:20]N1C(=O)CCC1=O.O>C(O)(=O)C>[Br:20][C:10]1[C:11](=[O:13])[NH:12][C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[N:8][C:9]=1[C:14]1[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=1

Participants

5

Reactant 3

HCID 962WaterHCID 67184N-bromobutanimideHCID 135512471HCID 135512471, compound

Product 1

HCID 135753977HCID 135753977, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
90 °C

Procedure

2-Phenyl-6-(4-pyridyl)pyrimidin-4-one (0.61 g) obtained in Example 12 was dissolved in 3 ml of acetic acid, and then the mixture was added with 0.48 g of N-bromosuccinimide and heated at 90° C. for 1 hour. Water was added to the reaction mixture, and solid mass was separated by filtration. The solid was washed with water, acetone, and ethyl acetate, and dried to obtain 0.74 g of the desired compound.

Workup

  1. customwas separated by filtration
  2. washThe solid was washed with water, acetone, and ethyl acetate
  3. customdried

Sources & evidence

ORD record
ord-0c6fc42c0abb4380aeac14b3b9c3cb46
Source dataset
uspto-grants-2007_08
Patent number
US07256199B1

Reaction notes

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