3-Chloro-4-methoxyaniline → HCID 69473762, compound

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Reaction Steps

According to synthetic methods F and G, N-(3-chloro-4-methoxy-phenyl)-N-[2-(3-methoxy-phenyl)-ethyl]-propionamide (0.753 g) was obtained from (3-methoxy-phenyl)-acetyl chloride (1.0 eq) and 3-chloro-4-methoxy-phenylamine (1.0 eq) followed by reaction with propionyl chloride (1.5 eq). MS: 348.4 (MH+); HPLC tR: 2.72 mm (method D); TLC Rf: 0.48 (ethyl acetate:hexane-1:1). According to synthetic methods H and B, the title compound (0.25 g) was obtained after purification by chromatography on silica gel (eluant: a gradient of 0 to 5% methanol in methylene chloride); MS: 304.2, 306.2 (MH+); HPLC tR: 1.80 min (method D); TLC Rf: 0.16 (2% methanol:methylene chloride).

Provenance & Evidence