Ethanol → HCID 131726547, compound

Participants

Reaction Steps

Continuing with Scheme 3, to a solution of 19 (380 mg, 0.90 mmol) in glacial acetic acid (13 mL), and ethanol (25 mL) was added 10% palladium on carbon (120 mg). The mixture was placed on Parr hydrogenation apparatus at 50 psi for 4 h at room temperature. The mixture was filtered through HYFLO® matrix (available from Word Minerals Corporation of Santa Barbara, Calif., United States of America) and the filter pad washed with water. The filtrate was evaporated under reduced pressure and the precipitate was collected and washed with ether to give 20, in 68% yield, mp 266–268° C.dec.

Provenance & Evidence