Tetrahydrofuran → HCID 9883721, compound

Participants

Reaction Steps

To a stirred cold suspension of 2,3-dioxo-2,3-dihydro-1H-indol-5-sulfonyl chloride (5.00 g, 20.4 mmol) in a 1:1 mixture of THF: CHCl3 (140 mL) was added dropwise, via syringe pump, a solution of N,N-diisopropylethylamine (7.11 mL, 40.8 mmol, 2 eq) and (R)-2-(Methoxymethyl)pyrrolidine (3.27 mL, 26.5 mmol, 1.3 eq) in CHCl3 (60 mL) over a period of 1.5 hours with cooling in an ice bath. After stirring an additional 1 h, the reaction was concentrated. The crude product was purified on Biotage KP silica gel eluting with 95/5 CH2Cl2/CH3OH followed by a second chromatography on silica gel eluting with EtOAc to give 4.21 g (63.8% ) of the title compound. NMR (400 MHz, DMSO-d6): consistent.

Provenance & Evidence