Acrylonitrile → HCID 58932547, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of N-benzyl-N-methyl-2′-oxo-1′,2′-dihydrospiro[1,3-dioxane-2,3′-indole]-5′-sulfonamide (1.00 g, 2.57 mmol) and benzyltrimethylammonium hydroxide (40% aqueous sol'n, 0.112 mL, 0.617 mmol, 0.24 mole % ) in absolute EtOH (20 mL) was heated to 78° C. and acrylonitrile (0.424 mL, 6.44 mmol, 2.5 eq) was added drop-wise. The reaction mixture was heated for 40 minutes longer, cooled to room temperature and filtered. The product was washed with ethanol and dried to give the title compound as a white solid (0.95 g, 84% yield). NMR (300 MHz, DMSO-d6): consistent.

Provenance & Evidence