Sodium Chloride → HCID 11682171, compound

Participants

Reaction Steps

To a solution of N-(3′,3′-dimethyl-3′,4′-dihydro-2′H-spiro[1,3-dioxane-2,10′-pyrimido[1,2-a]indol]-8′-yl)benzenesulfonamide (0.064 g, 0.14 mmol, 1 eq) in CH2Cl2 (4 mL) was added methanesulfonic acid (2 mL). The reaction was stirred at rt overnight and then poured into brine. It was basified to pH 10, saturated with solid NaCl, and extracted with EtOAc. The combined organics were dried over sodium sulfate and concentrated. The crude residue purified by column chromatography using acetone/hexanes (40/60) as an eluent to give the title compound as a yellow foam (0.032 g, 58% ). NMR (400 Mz, DMSO-d6): consistent. MS: (ES−) m/z 368 [M−H].

Provenance & Evidence