HuagongsheHuagongshe Chemistry Print Report · For research reference only
5'-{[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonyl}spiro[1,3-dioxane-2,3'-indol]-2'(1'H)-one → Pyrimidoindolone, 25b
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5'-{[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonyl}spiro[1,3-dioxane-2,3'-indol]-2'(1'H)-one | HCID 25269014 | — |
| Reactant | 1-(Chloromethyl)cyclobutane-1-carbonitrile | HCID 55298189 | — |
| Product | Pyrimidoindolone, 25b | HCID 11626852 | — |
Reaction Steps
The title compound was prepared as a yellow foam from 5′-{[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonyl}spiro[1,3-dioxane-2,3′-indol]-2′(1′H)-one and 1-chloromethyl-cyclobutanecarbonitrile (Syn. Comm. 20(12) 1757, 1990) using a procedure similar to that of steps 3-5 of Example 12. NMR (400 Mz, DMSO-d6): consistent. MS: (ES−) m/z 464 [M−H].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07256198B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-23cd27d67deb4694be53f3bc90a71a78 |
| Source note | uspto-grants-2007_08 |