反应详情

A mixture of 3-[5′-{[pyrrolidin-1-yl]sulfonyl}-2′-oxospiro[1,3-dioxane-2,3′-indol]-1′(2′H)-yl]-2-azidobutane (0.16 g, 0.37 mmoles) and 10% Pd/C in methanol (5 ml) was stirred under a H2 atmosphere (1 atmosphere) overnight at room temperature. The reaction mixture was filtered, and concentrated. The crude product was purified by flash chromatography on silica gel using 40% EtOAc/hexane followed by 1% CH3OH/EtOAc to give the title compound as an off white solid (0.06 g, 40% yield). NMR (400 MHz, DMSO-d6): consistent. MS: (API-ES+) m/z 410 [M+H].

1. filtrationThe reaction mixture was filtered
2. concentrationconcentrated
3. customThe crude product was purified by flash chromatography on silica gel using 40% EtOAc/hexane