3-(Trifluoromethyl)benzaldehyde → HCID 91507621, compound

HRID 853934Notes

Reaction equation

HRID 853934 reaction equation
[CH3:1][C:2]([C:4]1[CH:9]=[C:8]([O:10][CH2:11][C:12]([F:15])([F:14])[F:13])[CH:7]=[CH:6][C:5]=1[O:16][CH2:17][C:18]([F:21])([F:20])[F:19])=[O:3].[F:22][C:23]([F:33])([F:32])[C:24]1[CH:25]=[C:26]([CH:29]=[CH:30][CH:31]=1)[CH:27]=O>>[F:21][C:18]([F:19])([F:20])[CH2:17][O:16][C:5]1[CH:6]=[CH:7][C:8]([O:10][CH2:11][C:12]([F:13])([F:14])[F:15])=[CH:9][C:4]=1[C:2](=[O:3])[CH:1]=[CH:27][C:26]1[CH:29]=[CH:30][CH:31]=[C:24]([C:23]([F:22])([F:32])[F:33])[CH:25]=1

Participants

3

Reactant 2

HCID 679903-(Trifluoromethyl)benzaldehydeHCID 27360731-(2,5-Bis(2,2,2-trifluoroethoxy)phenyl)ethan-1-one

Product 1

HCID 91507621HCID 91507621, compound

Procedure

The title compound was prepared from a mixture of 2,5-bis(2,2,2-trifluoroethoxy)acetophenone (200 mg, 0.633 mmol) and 3-(trifluoromethyl)benzaldehyde (85 ul, 0.633 mmol) similar to Example 6 and isolated as a yellow solid (88 mg, 30%). 1H NMR (CDCl3): 7.86 (s, 1H), 7.76-7.50 (m, 5H), 7.35 (d, J=3.0 Hz, 1H), 7.14 (dd, J=3.3, 9.3 Hz, 1H), 6.94 (d, J=9.0 Hz, 1H), 4.47-4.32 (m, 4H).

Sources & evidence

ORD record
ord-9b6c6301bd1d421698f798f36c31ebb9
Source dataset
uspto-grants-2007_08
Patent number
US07256219B2

Reaction notes

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