o-(Trifluoromethyl)benzaldehyde → HCID 91004828, compound

HRID 853935Notes

Reaction equation

HRID 853935 reaction equation
[CH3:1][C:2]([C:4]1[CH:9]=[C:8]([O:10][CH2:11][C:12]([F:15])([F:14])[F:13])[CH:7]=[CH:6][C:5]=1[O:16][CH2:17][C:18]([F:21])([F:20])[F:19])=[O:3].[F:22][C:23]([F:33])([F:32])[C:24]1[CH:31]=[CH:30][CH:29]=[CH:28][C:25]=1[CH:26]=O>>[F:21][C:18]([F:19])([F:20])[CH2:17][O:16][C:5]1[CH:6]=[CH:7][C:8]([O:10][CH2:11][C:12]([F:13])([F:14])[F:15])=[CH:9][C:4]=1[C:2](=[O:3])[CH:1]=[CH:26][C:25]1[CH:28]=[CH:29][CH:30]=[CH:31][C:24]=1[C:23]([F:22])([F:32])[F:33]

Participants

3

Reactant 2

HCID 123067o-(Trifluoromethyl)benzaldehydeHCID 27360731-(2,5-Bis(2,2,2-trifluoroethoxy)phenyl)ethan-1-one

Product 1

HCID 91004828HCID 91004828, compound

Procedure

The title compound was prepared from a mixture of 2,5-bis(2,2,2-trifluoroethoxy)acetophenone (200 mg, 0.633 mmol) and 2-(trifluoromethyl)benzaldehyde (83 ul, 0.633 mmol) similar to Example 6 and isolated as a pale white-yellow solid (26 mg, 9%). 1H NMR (CDCl3): 8.02 (d, J=16.5 Hz, 1H), 7.82 (d, J=7.5 Hz, 1H), 7.72 (d, J=7.5 Hz, 1H), 7.62-7.47 (m, 2H), 7.39 (d, J=15.6 Hz, 1H), 7.29 (d, J=3.3 Hz, 1H), 7.14 (dd, J=3.2, 8.9 Hz, 1H), 6.95 (d, J=9.0 Hz, 1H).

Sources & evidence

ORD record
ord-a5d3f87e3690457b993892b2b72cafa6
Source dataset
uspto-grants-2007_08
Patent number
US07256219B2

Reaction notes

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