2-Chlorobenzaldehyde → HCID 85331615, compound

Participants

Reaction Steps

The title compound was prepared from a mixture of 2,5-bis(2,2,2-trifluoroethoxy)acetophenone (100 mg, 0.317 mmol) and 2-chlorobenzaldehyde (36 ul, 0.317 mmol) similar to Example 6. The residue was purified with hexane:ethylacetate (5:1, 4:1) to yield a light yellow solid (13.5 mg, 9.7%). 1H NMR (CDCl3): 8.10 (d, J=15.6 Hz, 1H), 7.73 (dd, J=2.3, 7.1 Hz, 1H), 7.43 (d, J=9.3 Hz, 1H), 7.41 (d, J=15.9 Hz, 1H), 7.33 (t, J=2.1 Hz, 1H), 7.32 (s, 1H), 7.3 (d, J=3.0 Hz, 1H), 7.14 (dd, J=3.2 Hz, 9.2, 1H), 6.96 (d, J=9.0 Hz, 1H), 4.45-4.34 (m, 4H).

Provenance & Evidence