4-Nitrobenzaldehyde → HCID 91452445, compound

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Reaction Steps

The title compound was prepared by stirring a mixture of 2,5-bis(2,2,2-trifluoroethoxy)acetophenone (200 mg, 0.633 mmol), 4-nitrobenzaldehyde (96 mg, 0.633 mmol), ethanol (5 ml) and saturated NaOH (50 ul) at room temperature for 4 h. The mixture was diluted with ethyl acetate (100 ml), washed with water and saturated NaCl. The crude was dried over anhydrous sodium sulfate and then concentrated in vacuo. The residue was purified by column chromatography using hexane:ethyl acetate (4:1, 3:1) to give a yellow solid (33 mg, 12%). 1H NMR (CDCl3): 8.26 (d, J=9.0 Hz, 2H), 7.74 (d, J=9.0 Hz, 2H), 7.72 (d, J=16.2 Hz, 1H), 7.61 (d, J=15.6 Hz, 1H), 7.36 (d, J=3.0 Hz, 1H), 7.18 (dd, J=3.3, 9.0 Hz, 1H), 6.96 (d, J=9.0 Hz, 1H), 4.49-4.35 (m, 4H).

Provenance & Evidence