1-(2,5-Bis(2,2,2-trifluoroethoxy)phenyl)ethan-1-one → 1-[2,5-Bis(2,2,2-trifluoroethoxy)phenyl]-3-[3-fluoro-4-(trifluoromethyl)phenyl]prop-2-en-1-one

Participants

Reaction Steps

The title compound was prepared from a mixture of 2,5-bis(2,2,2-trifluoroethoxy)acetophenone (200 mg, 0.633 mmol) and 3-fluoro-4-(trifluoromethyl)benzaldehyde (91 ul, 0.633 mmol) similar to Example 18 as a yellow solid (164 mg, 53%). 1H NMR (CDCl3): 7.65-7.60 (m, 2H), 7.52 (d, J=15.9 Hz, 1H), 7.43-7.37 (m, 2H), 7.32 (d, J=3.3 Hz, 1H), 7.15 (dd, J=3.3, 8.7 Hz, 1H), 6.92 (d, J=9.0 Hz, 1H), 4.45-4.32 (m, 4H).

Provenance & Evidence