2-Hydroxy-4-(trifluoromethyl)benzoic acid → HCID 59193198, compound

HRID 85397Notes

Reaction equation

HRID 85397 reaction equation
[C:1]([O:24][C:25]1[CH:30]=[CH:29][C:28](C2C=CC(F)=CC=2F)=[CH:27][C:26]=1[C:39]([O:41][CH2:42][CH3:43])=[O:40])(=[O:23])[CH2:2][CH2:3]/[CH:4]=[CH:5]\[CH2:6]/[CH:7]=[CH:8]\[CH2:9]/[CH:10]=[CH:11]\[CH2:12]/[CH:13]=[CH:14]\[CH2:15]/[CH:16]=[CH:17]\[CH2:18]/[CH:19]=[CH:20]\[CH2:21][CH3:22].OC1C=C([C:54]([F:57])([F:56])[F:55])C=CC=1C(O)=O>>[C:1]([O:24][C:25]1[CH:30]=[C:29]([C:54]([F:57])([F:56])[F:55])[CH:28]=[CH:27][C:26]=1[C:39]([O:41][CH2:42][CH3:43])=[O:40])(=[O:23])[CH2:2][CH2:3]/[CH:4]=[CH:5]\[CH2:6]/[CH:7]=[CH:8]\[CH2:9]/[CH:10]=[CH:11]\[CH2:12]/[CH:13]=[CH:14]\[CH2:15]/[CH:16]=[CH:17]\[CH2:18]/[CH:19]=[CH:20]\[CH2:21][CH3:22]

Participants

3

Reactant 2

HCID 1645782-Hydroxy-4-(trifluoromethyl)benzoic acidHCID 59193252HCID 59193252, compound

Product 1

HCID 59193198HCID 59193198, compound

Procedure

Ethyl 2-((4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoyloxy)-4-(trifluoromethyl)benzoate was prepared in a similar fashion as ethyl 4-((4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoyloxy)-2′,4′-difluorobiphenyl-3-carboxylate, using the appropriate 2-hydroxy-4-(trifluoromethyl)benzoic acid starting material. Mass calculated for C32H39F3O4=544.64; found: [M+Na]+=567.3.

Sources & evidence

ORD record
ord-587b8e1f46cf4d33bd253f4ce593b2f5
Source dataset
uspto-grants-2014_09
Patent number
US08846972B2

Reaction notes

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