HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 2-(2-(2-(2-hydroxybenzamido)ethyl)disulfanyl)ethylcarbamate → N-(2-(2-(2-aminoethyl)-disulfanyl)-ethyl)-2-hydroxybenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 2-(2-(2-(2-hydroxybenzamido)ethyl)disulfanyl)ethylcarbamate | HCID 86643520 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | N-(2-(2-(2-aminoethyl)-disulfanyl)-ethyl)-2-hydroxybenzamide | HCID 58218979 | — |
Reaction Steps
tert-Butyl 2-(2-(2-(2-hydroxybenzamido)ethyl)disulfanyl)ethylcarbamate (400 mg, 1.08 mmol) was taken up in 25% TFA in CH2Cl2 (10 mL) and allowed to stand at room temperature for 3 h. The reaction mixture was concentrated under reduced pressure to afford a quantitative yield of N-(2-(2-(2-aminoethyl)-disulfanyl)-ethyl)-2-hydroxybenzamide as the TFA salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08846972B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-fda4b43a7e0c406db1d797fd0ffdf68c |
| Source note | uspto-grants-2014_09 |