Fumaric Acid → HCID 18361543, compound

HRID 854042Notes

Reaction equation

HRID 854042 reaction equation
[C:1]1([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:6]=[CH:5][C:4]([CH2:7][O:8][C:9]2[CH:10]=[C:11]3[C:16](=[CH:17][CH:18]=2)[CH2:15][CH:14]([CH2:19][CH2:20][N:21]([CH3:23])[CH3:22])[CH2:13][CH2:12]3)=[CH:3][CH:2]=1.[C:30]([OH:37])(=[O:36])/[CH:31]=[CH:32]/[C:33]([OH:35])=[O:34]>CO>[C:30]([OH:37])(=[O:36])/[CH:31]=[CH:32]/[C:33]([OH:35])=[O:34].[C:1]1([C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH:2]=[CH:3][C:4]([CH2:7][O:8][C:9]2[CH:10]=[C:11]3[C:16](=[CH:17][CH:18]=2)[CH2:15][CH:14]([CH2:19][CH2:20][N:21]([CH3:23])[CH3:22])[CH2:13][CH2:12]3)=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 444972Fumaric AcidHCID 9823548HCID 9823548, compound

Product 1

HCID 18361543HCID 18361543, compoundYield 41.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To a solution of (−)-6-(4-biphenylyl)methoxy-2-[2-(N,N-dimethylamino)ethyl]tetralin (1.3 g) in methanol (10 ml) was added a solution of fumaric acid (0.39 g) in methanol (10 ml) and concentrated. The resulting salt was recrystallized from methanol to obtain the titled compound (0.7 g).

Workup

  1. concentrationconcentrated
  2. customThe resulting salt was recrystallized from methanol

Sources & evidence

ORD record
ord-3c21d6c5d8224c2186960d825397eb33
Source dataset
uspto-grants-2007_08
Patent number
US07256204B2

Reaction notes

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