HRID854042

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID444972

Fumaric acid

C4H4O4

结构：CN(C)CCC1CCc2cc(OCc3ccc(-c4ccccc4)cc3)ccc2C1

HCID9823548

未命名化合物

PRODUCTS

生成物

结构：CN(C)CCC1CCc2cc(OCc3ccc(-c4ccccc4)cc3)ccc2C1.O=C(O)/C=C/C(=O)O

HCID18361543

未命名化合物

收率 41.5%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

2 次

PROCEDURE

实验过程

To a solution of (−)-6-(4-biphenylyl)methoxy-2-[2-(N,N-dimethylamino)ethyl]tetralin (1.3 g) in methanol (10 ml) was added a solution of fumaric acid (0.39 g) in methanol (10 ml) and concentrated. The resulting salt was recrystallized from methanol to obtain the titled compound (0.7 g).

WORKUP

后处理

concentrationconcentrated
customThe resulting salt was recrystallized from methanol

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3c21d6c5d8224c2186960d825397eb33
来源数据集: uspto-grants-2007_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07256204B2
来源说明: uspto-grants-2007_08

反应 SMILES

[C:1]1([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:6]=[CH:5][C:4]([CH2:7][O:8][C:9]2[CH:10]=[C:11]3[C:16](=[CH:17][CH:18]=2)[CH2:15][CH:14]([CH2:19][CH2:20][N:21]([CH3:23])[CH3:22])[CH2:13][CH2:12]3)=[CH:3][CH:2]=1.[C:30]([OH:37])(=[O:36])/[CH:31]=[CH:32]/[C:33]([OH:35])=[O:34]>CO>[C:30]([OH:37])(=[O:36])/[CH:31]=[CH:32]/[C:33]([OH:35])=[O:34].[C:1]1([C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH:2]=[CH:3][C:4]([CH2:7][O:8][C:9]2[CH:10]=[C:11]3[C:16](=[CH:17][CH:18]=2)[CH2:15][CH:14]([CH2:19][CH2:20][N:21]([CH3:23])[CH3:22])[CH2:13][CH2:12]3)=[CH:5][CH:6]=1