Citric Acid → HCID 18361599, compound

HRID 854043Notes

Reaction equation

HRID 854043 reaction equation
[C:1]1([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:6]=[CH:5][C:4]([CH2:7][O:8][C:9]2[CH:10]=[C:11]3[C:16](=[CH:17][CH:18]=2)[CH2:15][CH:14]([CH2:19][CH2:20][N:21]([CH3:23])[CH3:22])[CH2:13][CH2:12]3)=[CH:3][CH:2]=1.[C:30]([OH:42])(=[O:41])[CH2:31][C:32]([CH2:37][C:38]([OH:40])=[O:39])([C:34]([OH:36])=[O:35])[OH:33]>CO>[C:30]([OH:42])(=[O:41])[CH2:31][C:32]([CH2:37][C:38]([OH:40])=[O:39])([C:34]([OH:36])=[O:35])[OH:33].[C:1]1([C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH:2]=[CH:3][C:4]([CH2:7][O:8][C:9]2[CH:10]=[C:11]3[C:16](=[CH:17][CH:18]=2)[CH2:15][CH:14]([CH2:19][CH2:20][N:21]([CH3:23])[CH3:22])[CH2:13][CH2:12]3)=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 311Citric AcidHCID 9823548HCID 9823548, compound

Product 1

HCID 18361599HCID 18361599, compoundYield 97.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To a solution of (−)-6-(4-biphenylyl)methoxy-2-[2(N,N-dimethylamino)ethyl]tetralin (1.3 g) in methanol (10 ml) was added a solution of citric acid (0.65 g) in methanol (10 ml) and the resulting precipitated salt was collected by filtration and washed with methanol, ethyl acetate, and diethyl ether to obtain the titled compound (1.9 g).

Workup

  1. customthe resulting precipitated salt
  2. filtrationwas collected by filtration
  3. washwashed with methanol, ethyl acetate, and diethyl ether

Sources & evidence

ORD record
ord-83f10601adfc4bd380a1c18b47881dad
Source dataset
uspto-grants-2007_08
Patent number
US07256204B2

Reaction notes

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