Ammonia → 2,3-Diamino-6-methoxypyridine

HRID 854070Notes

Reaction equation

HRID 854070 reaction equation
Cl.Cl.[NH2:3][C:4]1[C:9]([NH2:10])=[CH:8][CH:7]=[C:6]([O:11][CH3:12])[N:5]=1.N>O>[NH2:3][C:4]1[C:9]([NH2:10])=[CH:8][CH:7]=[C:6]([O:11][CH3:12])[N:5]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 30239196-Methoxy-2,3-pyridinediamine HCl

Product 1

HCID 30239202,3-Diamino-6-methoxypyridineYield 92%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
15 °C

Procedure

2,3-Diamino-6-methoxypyridine dihydrochloride, 25.0 gm (0.117 mole) was suspended in water (50.0 ml) and the mixture was cooled to 15° C. After cooling, the reaction mixture was neutralized with 25% aqueous ammonia solution to the pH of 7.0 to 8.0. The separated precipitate was stirred for half an hour and then filtered out. After drying under vacuum 14.95 gm of 2,3-diamino-6-methoxypyridine (92.0% yield) was obtained with a purity of 99.01% by HPLC.

Workup

  1. temperatureAfter cooling
  2. filtrationfiltered out

Sources & evidence

ORD record
ord-47b101432e394821be9d0e1a8c7eb086
Source dataset
uspto-grants-2007_08
Patent number
US07256295B2

Reaction notes

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