1-Butanol → HCID 87556830, compound

Participants

Reaction Steps

In a 50 mL-volumetric autoclave were added deaerated n-butanol (20 mL), and thereto were added 4-aminopyridine (47 mg, 0.5 mmol) and (R)-ethylglycidyl ether (2.0 g, 20 mmol, >99% ee). Then to the mixture was added crystalline dicobaltoctacarbonyl complex (171 mg, 0.5 mmol). After covering the autoclave with a cap, carbon monoxide (1 MPa) was introduced therein and the mixture was reacted at 45° C. for 12 hours. After cooling to room temperature, the solvent was removed in vacuo. The residue was subjected to Kugelrohr distillation to give (R)-4-ethoxy-3-hydroxybutanoic acid n-butyl ester (3.7 g, 90%, >99% ee) as a colorless oil.

Provenance & Evidence