4-Aminopyridine → HCID 11052254, compound

Participants

Reaction Steps

In a 50 mL-volumeric autoclave were added deaerated isopropanol (20 mL), 4-aminopyridine 47 mg (0.5 mmol) and (S)-epichlorohydrin (1.9 g, 20 mmol, >99% ee). Then to the mixture was added crystalline dicobaltoctacarbonyl complex (171 mg, 0.5 mmol). After covering the autoclave with a cap, carbon monoxide (1.5 MPa) was introduced therein and the mixture was reacted at 40° C. for 25 hours. After cooling to room temperature, the solvent was removed in vacuo. The residue was subjected to Kugelrohr distillation to give (S)-4-chloro-3-hydroxybutanoic acid isopropyl ester (2.7 g, 80%, >99% ee) as a colorless oil.

Provenance & Evidence