Methanol → HCID 15190010, compound

Participants

Reaction Steps

In a 50 mL-volumetric autoclave were added deaerated methanol (10 mL) and t-amyl alcohol (10 mL), and thereto were added 4-aminopyridine (47 mg, 0.5 mmol) and (S)-methylglycidyl ether (1.8 g, 20 mmol, >99% ee). Then to the mixture was added crystalline dicobaltoctacarbonyl complex (171 mg, 0.5 mmol). After covering the autoclave with a cap, carbon monoxide (1 MPa) was introduced therein and the mixture was reacted at 40° C. for 8 hours. After cooling to room temperature, the solvent was removed in vacuo. The residue was subjected to Kugelrohr distillation to give (S)-4-methoxy-3-hydroxybutanoic acid methyl ester (2.7 g, 92%, >99% ee) as a colorless oil.

Provenance & Evidence