Phenol → N,N'-Dicyclohexylurea

Participants

Reaction Steps

A solution of the alcohol or phenol (1.0 eq.), of the carboxylic acid (1.1 eq.), of N,N′-dicyclohexylcarbodiimide (Aldrich, purity 99%; about 1.1-1.7 eq.) and catalytic amounts of 4-pyrrolidinopyridine (Aldrich, purity 98%; about 0.01 eq.) is stirred in anhydrous dichloromethane until the reaction is complete. The N,N′-dicyclohexylurea formed is filtered off, the solvent is removed under reduced pressure, and the residue is purified as described.

Provenance & Evidence