HRID854249

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)[C@H](CNc1ncnc2c1ncn2CCCC(=O)NC1=NCCCN1)NC(=O)OCc1ccccc1

HCID15547266

未命名化合物

PRODUCTS

生成物

结构：O=C(CCCn1cnc2c(NC[C@H](NC(=O)OCc3ccccc3)C(=O)O)ncnc21)NC1=NCCCN1

HCID15547257

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID22392675

未命名化合物

PROCEDURE

实验过程

70 mg (Q.12 mmol) of (2S)-2-benzyloxycarbonylamino-3-{9-[3-(1,4,5,6-tetrahydro-pyrimidin-2-ylcarbamoyl)-propyl]-9H-purin-6-ylamino}-propionic acid tert-butyl ester was dissolved in 3 ml of trifluoroacetic acid/water (95/5). The solution was stirred at room temperature for 3 hours. The solvent was removed in vacuo and toluene was added to the residue and then removed in vacuo. The residue was dissolved in acetonitrile/water 1/1 and lyophilized. Yield: 51 mg (trifluoroacetate salt).

WORKUP

后处理

customThe solvent was removed in vacuo and toluene
additionwas added to the residue
customremoved in vacuo
dissolutionThe residue was dissolved in acetonitrile/water 1/1

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-35830b427dad41b291ce0bbbf227bea8
来源数据集: uspto-grants-2007_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07259159B2
来源说明: uspto-grants-2007_08

反应 SMILES

C([O:5][C:6](=[O:42])[C@@H:7]([NH:31][C:32]([O:34][CH2:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)=[O:33])[CH2:8][NH:9][C:10]1[N:18]=[CH:17][N:16]=[C:15]2[C:11]=1[N:12]=[CH:13][N:14]2[CH2:19][CH2:20][CH2:21][C:22](=[O:30])[NH:23][C:24]1[NH:25][CH2:26][CH2:27][CH2:28][N:29]=1)(C)(C)C>FC(F)(F)C(O)=O.O>[CH2:35]([O:34][C:32]([NH:31][C@@H:7]([CH2:8][NH:9][C:10]1[N:18]=[CH:17][N:16]=[C:15]2[C:11]=1[N:12]=[CH:13][N:14]2[CH2:19][CH2:20][CH2:21][C:22](=[O:30])[NH:23][C:24]1[NH:25][CH2:26][CH2:27][CH2:28][N:29]=1)[C:6]([OH:42])=[O:5])=[O:33])[C:36]1[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=1