HCID 15546708, compound → HCID 69033633, compound

HRID 854261Notes

Reaction equation

HRID 854261 reaction equation
[CH2:1]([O:3][C:4](=[O:19])[CH2:5][CH2:6][CH2:7][N:8]1[C:12]2[N:13]=[C:14]([CH3:18])[N:15]=[C:16](Cl)[C:11]=2[CH:10]=[CH:9]1)[CH3:2].[C:20]([O:24][C:25](=[O:43])[C@H:26]([CH2:41][SH:42])[NH:27][S:28]([C:31]1[C:40]2[C:35](=[CH:36][CH:37]=[CH:38][CH:39]=2)[CH:34]=[CH:33][CH:32]=1)(=[O:30])=[O:29])([CH3:23])([CH3:22])[CH3:21]>>[CH2:1]([O:3][C:4](=[O:19])[CH2:5][CH2:6][CH2:7][N:8]1[C:12]2[N:13]=[C:14]([CH3:18])[N:15]=[C:16]([S:42][CH2:41][C@H:26]([NH:27][S:28]([C:31]3[C:40]4[C:35](=[CH:36][CH:37]=[CH:38][CH:39]=4)[CH:34]=[CH:33][CH:32]=3)(=[O:30])=[O:29])[C:25]([O:24][C:20]([CH3:23])([CH3:21])[CH3:22])=[O:43])[C:11]=2[CH:10]=[CH:9]1)[CH3:2]

Participants

3

Reactant 2

HCID 15546708HCID 15546708, compoundHCID 86760529HCID 86760529, compound

Product 1

HCID 69033633HCID 69033633, compound

Procedure

Preparation in analogy to example 6c from 282 mg of 4-(4-chloro-2-methyl-pyrrolo[2,3-d]pyrimidin-7-yl)-butyric acid ethyl ester (example 2a) and 440 mg of N-(naphthalene-1-sulfonyl)-(R)-cysteine-tert-butyl ester. Yield: 110 mg.

Sources & evidence

ORD record
ord-8b8ef267f861439a9fdba7ec8289ce70
Source dataset
uspto-grants-2007_08
Patent number
US07259159B2

Reaction notes

Loading…