HCID 86607766, compound → HCID 55300257, compound

HRID 854275Notes

Reaction equation

HRID 854275 reaction equation
[CH3:1][C@@H:2]1[C:8](=[O:9])[NH:7][C@H:6]([CH3:10])[CH2:5][CH2:4][N:3]1C(OCC1C=CC=CC=1)=O>[Pd].CO>[CH3:1][C@H:2]1[NH:3][CH2:4][CH2:5][C@@H:6]([CH3:10])[NH:7][C:8]1=[O:9]

Participants

4

Reactant 1

HCID 86607766HCID 86607766, compound

Product 1

HCID 55300257HCID 55300257, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of benzyl (2R,5R)-2,5-dimethyl-3-oxo-1,4-diazepane-1-carboxylate (160 mg) and 10% palladium on carbon (32 mg) in methanol (15 mL) was stirred at room temperature overnight, filtered over Celite, and washed with 10% methanol in dichloromethane. The filtrate was concentrated under reduced pressure to yield the title compound. MS 143.1 (M+1).

Workup

  1. filtrationfiltered over Celite
  2. washwashed with 10% methanol in dichloromethane
  3. concentrationThe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-043b15390abc4899936358571054dfa7
Source dataset
uspto-grants-2007_08
Patent number
US07259160B2

Reaction notes

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