HCID 9902613, compound → HCID 58933866, compound

HRID 854290Notes

Reaction equation

HRID 854290 reaction equation
C(OC([N:11]1[CH2:16][CH2:15][CH:14]([CH2:17][NH:18][C:19]([C:21]2[CH:22]=[N:23][NH:24][CH:25]=2)=[O:20])[CH2:13][CH2:12]1)=O)C1C=CC=CC=1>[Pd].C(O)C>[NH:11]1[CH2:16][CH2:15][CH:14]([CH2:17][NH:18][C:19]([C:21]2[CH:25]=[N:24][NH:23][CH:22]=2)=[O:20])[CH2:13][CH2:12]1

Participants

4

Reactant 1

HCID 9902613HCID 9902613, compound

Product 1

HCID 58933866HCID 58933866, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

4-{[(1H-Pyrazole-4-carbonyl)-amino]-methyl}-piperidine-1-carboxylic acid benzyl ester (EXAMPLE 34) (600 mg, 1.75 mmol), 10% palladium on Carbon (150 mg) and ethanol (15 mL) were combined in a Parr® jar and hydrogenated at 50 psi for 24 h. The reaction mixture was filtered through Celite® and the filtrate was evaporated in vacuo to give the product as a white foam.

Workup

  1. filtrationThe reaction mixture was filtered through Celite®
  2. customthe filtrate was evaporated in vacuo

Sources & evidence

ORD record
ord-ac89ca70b7104aa09de3542f156d9a18
Source dataset
uspto-grants-2007_08
Patent number
US07259157B2

Reaction notes

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