Hydrochloric Acid → HCID 58933540, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-{[(2-diethoxymethyl-pyridine-4-carbonyl)-amino]-methyl}-piperidine-1-carboxylic acid benzyl ester (1.3 g, 0.0029 mol) in dioxane (20 mL) was added 1N hydrochloric acid (40 mL) and the mixture was warmed to 50° C. for 1.5 h. The reaction was cooled, diluted with ethyl acetate (100 mL) and 10% aqueous sodium bicarbonate (100 mL), and stirred well. The organic layer was removed, dried over sodium sulfate, filtered and concentrated in vacuo to give 4-{[(2-formyl-pyridine-4-carbonyl)-amino]-methyl}-piperidine-1-carboxylic acid benzyl ester as an oil.

Provenance & Evidence