HCID 58933540, compound → HCID 58933792, compound

Participants

Reaction Steps

To a solution of 4-{[(2-formyl-pyridine-4-carbonyl)-amino]-methyl}-piperidine-1-carboxylic acid benzyl ester (EXAMPLE 166, Step 6) (50 mg, 0.131 mmol) in TBF (2 mL) at −78° C. was added 3.0M methylmagnesium chloride (45 μL, 0.135 mmol). The mixture was stirred for 5 min and allowed to warm to rt. The reaction was diluted with 10% aqueous sodium bicarbonate (10 mL) and extracted with ethyl acetate (25 mL). The ethyl acetate extract was concentrated and chromatographed on silica using 100% ethyl acetate to ethyl acetate/methanol (95/5) to give the 4-({[2-(1-hydroxy-ethyl)-pyridine-4-carbonyl]-amino}-methyl)-piperidine-1-carboxylic acid benzyl ester.

Provenance & Evidence